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Submit ReviewPentostatin
Description: Adenosine deaminase inhibitor
Alternative Names: Deoxycoformycin
Chemical Name: (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
Purity: ≥99% (HPLC)
Biological Activity for Pentostatin
Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.
Technical Data for Pentostatin
| M. Wt | 268.27 |
| Formula | C11H16N4O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 53910-25-1 |
| PubChem ID | 439693 |
| InChI Key | FPVKHBSQESCIEP-JQCXWYLXSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CNC[C@H]3O)=C3N=C2)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pentostatin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.83 | 100 | |
| DMSO | 20.12 | 75 |
Preparing Stock Solutions for Pentostatin
The following data is based on the product molecular weight 268.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.73 mL | 18.64 mL | 37.28 mL |
| 5 mM | 0.75 mL | 3.73 mL | 7.46 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.73 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
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Product Datasheets for Pentostatin
References for Pentostatin
References are publications that support the biological activity of the product.
Klohs and Kraker (1992) Pentostatin: future directions. Pharmacol.Rev. 44 459 PMID: 1480666
Nabhan et al (2004) Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res. 28 429
If you know of a relevant reference for Pentostatin, please let us know.
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Keywords: Pentostatin, Pentostatin supplier, adenosines, deaminases, inhibitors, inhibits, antimetabolites, chemotherapeutics, Deoxycoformycin, Deaminases, 2033, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Pentostatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
3 Citations for Pentostatin
Citations are publications that use Tocris products. Selected citations for Pentostatin include:
Song (2017) Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun 8 14108 PMID: 28169986
Ledderose et al (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling PMID: 27577957
Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. PLoS Comput Biol 3 e00121 PMID: 26038697
Do you know of a great paper that uses Pentostatin from Tocris? Please let us know.
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