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Submit ReviewSpaglumic acid
Discontinued Product
0391 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
Description: Selective mGlu3 agonist
Alternative Names: α-NAAG
Chemical Name: N-Acetyl-L-aspartyl-L-glutamic acid
Purity: ≥96% (HPLC)
Biological Activity for Spaglumic acid
The most abundant peptide neurotransmitter in the mammalian CNS. A weak activator of NMDA receptors, and a highly selective agonist for mGlu3 receptors. Neuroprotective under non-hydrolysing conditions in vivo.
Technical Data for Spaglumic acid
| M. Wt | 304.26 |
| Formula | C11H16N2O8 |
| Storage | Store at -20°C |
| Purity | ≥96% (HPLC) |
| CAS Number | 3106-85-2 |
| PubChem ID | 188803 |
| InChI Key | OPVPGKGADVGKTG-BQBZGAKWSA-N |
| Smiles | CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Spaglumic acid
References for Spaglumic acid
References are publications that support the biological activity of the product.
Neale et al (2000) N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J.Neurochem. 75 443 PMID: 10899918
Thomas et al (2000) N-Acetylated α-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin. J.Pharmacol.Exp.Ther. 295 16 PMID: 10991955
Wroblewska et al (1997) N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J.Neurochem. 69 174 PMID: 9202308
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Keywords: Spaglumic acid, Spaglumic acid supplier, Putative, endogenous, neurotransmitter, Selective, mGlu3, agonists, Glutamate, mGlur, Receptors, Metabotropic, Group, II, iGluR, Ionotropic, alpha-NAAG, NAAG, a-NAAG, (Metabotropic), Miscellaneous, 0391, Tocris Bioscience
2 Citations for Spaglumic acid
Citations are publications that use Tocris products. Selected citations for Spaglumic acid include:
Kolodziejczyk et al (2009) The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes. Brain 132 1496 PMID: 19383832
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.