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Submit Review187-1, N-WASP inhibitor
Description: N-WASP inhibitor; inhibits actin assembly
Biological Activity for 187-1, N-WASP inhibitor
Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization.
Technical Data for 187-1, N-WASP inhibitor
| M. Wt | 1784.13 |
| Formula | C96H122N18O16 |
| Sequence |
KFPFFPQ KFPFFPQ (Modifications: Phe-2 = D-Phe, Pro-3 = D-Pro, Phe-4 = D-Phe, Pro-6 = D-Pro, Cyclized) |
| Storage | Desiccate at -20°C |
| CAS Number | 380488-27-7 |
| PubChem ID | 44405676 |
| InChI Key | PHTIQAVQWWOKNF-RNEDXEELSA-N |
| Smiles | NCCCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CC2=CC=CC=C2)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 187-1, N-WASP inhibitor
References for 187-1, N-WASP inhibitor
References are publications that support the biological activity of the product.
Suetsugu et al (2001) Identification of another actin-related (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J.Biol.Chem. 276 33175 PMID: 11432863
Prehoda and Lim (2002) How signaling proteins integrate multiple inputs: a comparison of N-WASP and cdk2. Curr.Opin.Cell Biol. 14 149 PMID: 11891112
Peterson et al (2001) A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc.Natl.Acad.Sci.USA 98 10624
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Keywords: 187-1, N-WASP inhibitor, 187-1, N-WASP inhibitor supplier, inhibitors, inhibits, actin, assembly, neural, Wiskott-Aldrich, syndrome, protein, Actin, 2067, Tocris Bioscience
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