Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewN-Acetyl-L-leucyl-L-leucyl-L-methional
Discontinued Product
This product has been withdrawn from sale and is superseded by E 64d (Cat. No. 4545)
Description: Cathepsin inhibitor
Biological Activity for N-Acetyl-L-leucyl-L-leucyl-L-methional
Very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.
Technical Data for N-Acetyl-L-leucyl-L-leucyl-L-methional
| M. Wt | 401.56 |
| Formula | C19H35N3O4S |
| Storage | Store at -20°C |
| CAS Number | 145757-50-2 |
| PubChem ID | 4331 |
| InChI Key | RJWLAIMXRBDUMH-UHFFFAOYSA-N |
| Smiles | O=C(C)NC(C(NC(C(NC(C([H])=O)CCSC)=O)CC(C)C)=O)CC(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for N-Acetyl-L-leucyl-L-leucyl-L-methional
References for N-Acetyl-L-leucyl-L-leucyl-L-methional
References are publications that support the biological activity of the product.
Francis et al (1997) Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II. J.Biol.Chem. 272 14961 PMID: 9169469
Sasaki et al (1990) Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195 PMID: 2079636
View Related Products by Target
View Related Products by Product Action
Keywords: N-Acetyl-L-leucyl-L-leucyl-L-methional, N-Acetyl-L-leucyl-L-leucyl-L-methional supplier, Cathepsin, L, B, inhibitors, inhibits, Proteinases, Proteases, Acetylleucylleucylmethional, 136632-32-1, Calcium-Sensitive, 0384, Tocris Bioscience
Citations for N-Acetyl-L-leucyl-L-leucyl-L-methional
Citations are publications that use Tocris products.
Currently there are no citations for N-Acetyl-L-leucyl-L-leucyl-L-methional.
Reviews for N-Acetyl-L-leucyl-L-leucyl-L-methional
There are currently no reviews for this product. Be the first to review N-Acetyl-L-leucyl-L-leucyl-L-methional and earn rewards!
Have you used N-Acetyl-L-leucyl-L-leucyl-L-methional?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image