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Submit ReviewSU 4312
Description: Potent inhibitor of VEGFR tyrosine kinase
Alternative Names: DMBI
Chemical Name: 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one
Biological Activity for SU 4312
SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Selective over EGFR and c-Src tyrosine kinases.
Technical Data for SU 4312
| M. Wt | 264.33 |
| Formula | C17H16N2O |
| Storage | Desiccate at -20°C |
| CAS Number | 5812-07-7 |
| PubChem ID | 6450842 |
| InChI Key | UAKWLVYMKBWHMX-PTNGSMBKSA-N |
| Smiles | CN(C)C1=CC=C(C=C1)\C=C1/C(=O)NC2=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SU 4312
References for SU 4312
References are publications that support the biological activity of the product.
Kendall et al (1999) Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J.Biol.Chem. 274 6453 PMID: 10037737
Sun et al (1998) Synthesis and biological evaluations of 3-substituted indol-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J.Med.Chem. 41 2588 PMID: 9651163
Zaman et al (1998) Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor β-receptor (β-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases. Biochem.Pharmacol. 57 57 PMID: 9920285
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Keywords: SU 4312, SU 4312 supplier, Potent, inhibitors, inhibits, VEGFR, tyrosine, kinase, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, Receptor, Tyrosine, Kinases, RTKs, SU4312, DMBI, 1459, Tocris Bioscience
1 Citation for SU 4312
Citations are publications that use Tocris products. Selected citations for SU 4312 include:
Cole et al (2010) Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis. PLoS One 5 e11644 PMID: 20657775
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Pathways for SU 4312
