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Submit ReviewAlrestatin
Description: Aldose reductase inhibitor
Chemical Name: 1,3-Dioxo-1H-benz[d,e]isoquinoline-2(3H)-acetic acid
Biological Activity for Alrestatin
Alrestatin is a specific inhibitor of aldose reductase (IC50 = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.
Technical Data for Alrestatin
| M. Wt | 255.23 |
| Formula | C14H9NO4 |
| Storage | Store at RT |
| CAS Number | 51411-04-2 |
| PubChem ID | 2120 |
| InChI Key | GCUCIFQCGJIRNT-UHFFFAOYSA-N |
| Smiles | OC(=O)CN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Alrestatin
References for Alrestatin
References are publications that support the biological activity of the product.
Barski et al (1996) The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry 35 14276 PMID: 8916913
Ehrig et al (1994) Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors. Biochemistry 33 7157 PMID: 8003482
Lavrentyev et al (2007) Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells. Circ.Res. 101 455 PMID: 17626897
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Keywords: Alrestatin, Alrestatin supplier, Aldose, reductases, inhibitors, inhibits, Carbohydrate, Metabolism, Reductase, 0485, Tocris Bioscience
3 Citations for Alrestatin
Citations are publications that use Tocris products. Selected citations for Alrestatin include:
Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98 PMID: 22654757
Lavrentyev and Malik (2009) High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. Am J Physiol Heart Circ Physiol 296 H106 PMID: 18978194
Mochin et al (2015) Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. PLoS One 97 55 PMID: 25283348
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