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Submit Review(RS)-AMPA hydrobromide
Description: Selective AMPA agonist; more water soluble form of (RS)-AMPA (Cat. No. 0169)
Chemical Name: (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hydrobromide
Purity: ≥99% (HPLC)
Biological Activity for (RS)-AMPA hydrobromide
(RS)-AMPA hydrobromide is a more water soluble hydrobromide salt of (RS)-AMPA (Cat. No. 0169).
Technical Data for (RS)-AMPA hydrobromide
| M. Wt | 267.08 |
| Formula | C7H10N2O4.HBr |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 171259-81-7 |
| PubChem ID | 11957558 |
| InChI Key | KUAHVIUZGLGASU-UHFFFAOYSA-N |
| Smiles | Br.CC1=C(CC(N)C(O)=O)C(O)=NO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (RS)-AMPA hydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.67 | 10 with gentle warming |
Preparing Stock Solutions for (RS)-AMPA hydrobromide
The following data is based on the product molecular weight 267.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.44 mL | 187.21 mL | 374.42 mL |
| 0.5 mM | 7.49 mL | 37.44 mL | 74.88 mL |
| 1 mM | 3.74 mL | 18.72 mL | 37.44 mL |
| 5 mM | 0.75 mL | 3.74 mL | 7.49 mL |
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Product Datasheets for (RS)-AMPA hydrobromide
References for (RS)-AMPA hydrobromide
References are publications that support the biological activity of the product.
Honore et al (1982) The binding of 3H-AMPA, a structural analogue of glutamic acid, to rat brain membranes. J.Neurochem. 38 173 PMID: 6125564
Krogsgaard-Larsen et al (1980) New class of glutamate agonist structurally related to ibotenic acid. Nature 284 64 PMID: 6101908
Ko et al (2021) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 13 PMID: 33918958
If you know of a relevant reference for (RS)-AMPA hydrobromide, please let us know.
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Keywords: (RS)-AMPA hydrobromide, (RS)-AMPA hydrobromide supplier, water, soluble, Glutamate, AMPA, Receptors, iGlur, Ionotropic, 1074, Tocris Bioscience
5 Citations for (RS)-AMPA hydrobromide
Citations are publications that use Tocris products. Selected citations for (RS)-AMPA hydrobromide include:
Chanda et al (2013) Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. J Psychopharmacol 110 16622 PMID: 24046374
Goo et al (2017) Activity-dependent trafficking of lysosomes in dendrites and dendritic spines. J Cell Biol 216 2499 PMID: 28630145
Iskandrani et al (2015) Impact of subanesthetic doses of KA on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons. J Neurosci 29 792 PMID: 25759403
Pierrot et al (2019) Sex-regulated gene dosage effect of PPARα on synaptic plasticity. Life Sci Alliance 2 PMID: 30894406
Wasling et al (2012) AMPA receptor activation causes silencing of AMPA receptor-mediated synaptic transmission in the developing hippocampus. PLoS One 7 e34474 PMID: 22485173
Do you know of a great paper that uses (RS)-AMPA hydrobromide from Tocris? Please let us know.
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