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Description: NMDA antagonist; acts at glycine site
Chemical Name: 1-Aminocyclobutane-1-carboxylic acid
Biological Activity for ACBC
ACBC is a NMDA receptor partial agonist, acting at the glycine site of GluN1 (formally NR1).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data for ACBC
| M. Wt | 115.13 |
| Formula | C5H9NO2 |
| Storage | Store at RT |
| CAS Number | 22264-50-2 |
| PubChem ID | 89643 |
| InChI Key | FVTVMQPGKVHSEY-UHFFFAOYSA-N |
| Smiles | NC1(CCC1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ACBC
References for ACBC
References are publications that support the biological activity of the product.
Hood et al (1989) 1-Aminocyclobutane-1-carboxylic acid (ACBC): a specific antagonist of the NMDA receptor coupled glycine receptor. Eur.J.Pharmacol. 161 281 PMID: 2542048
Inanobe et al (2005) Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron 47 71 PMID: 15996549
Rao et al (1990) Neuropharmacological characterization of 1-aminocyclopropane-1-carboxylate and 1-aminocyclobutane-1-carboxylate, ligands of the N-MthD.-aspartate-associated glycine receptor. Neuropharmacology 29 305 PMID: 2158004
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Keywords: ACBC, ACBC supplier, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, GluN1, NR1, 0258, Tocris Bioscience
Citations for ACBC
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Currently there are no citations for ACBC.
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