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Submit ReviewA-7 hydrochloride
Description: Calmodulin antagonist
Chemical Name: N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Biological Activity for A-7 hydrochloride
A-7 hydrochloride is a potent calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC50 of 3 μM).
Technical Data for A-7 hydrochloride
| M. Wt | 433.44 |
| Formula | C20H29ClN2O2S.HCl |
| Storage | Store at RT |
| CAS Number | 79127-24-5 |
| PubChem ID | 2735312 |
| InChI Key | XDJCAQBTSCRBHS-UHFFFAOYSA-N |
| Smiles | Cl.NCCCCCCCCCCNS(=O)(=O)C1=C2C=CC=C(Cl)C2=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for A-7 hydrochloride
References for A-7 hydrochloride
References are publications that support the biological activity of the product.
Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736
Itoh and Hidaka (1984) Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J.Biochem. 96 1721 PMID: 6099352
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Keywords: A-7 hydrochloride, A-7 hydrochloride supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Ca2+-calmodulin-dependent, phosphodiesterase, 0378, Tocris Bioscience
Citations for A-7 hydrochloride
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