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Submit Review[Ala11,D-Leu15]-Orexin B
Description: Potent and selective OX2 agonist
Purity: ≥95% (HPLC)
Biological Activity for [Ala11,D-Leu15]-Orexin B
[Ala11,D-Leu15]-Orexin B is a highly potent and selective OX2 receptor agonist; displays 400-fold selectivity over OX1 receptors. EC50 values are 0.13 and 52 nM for human OX2 and OX1 receptors respectively.
Technical Data for [Ala11,D-Leu15]-Orexin B
| M. Wt | 2857.28 |
| Formula | C120H206N44O35S |
| Sequence |
RSGPPGLQGRAQRLLQASGNHAAGILTM (Modification: Leu-15 = D-Leu, Met-28 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 532932-99-3 |
| PubChem ID | 16201464 |
| InChI Key | SURUUKNICBOUOQ-JNZZMZGCSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for [Ala11,D-Leu15]-Orexin B
| Solubility | Soluble to 0.30 mg/ml in water |
Product Datasheets for [Ala11,D-Leu15]-Orexin B
References for [Ala11,D-Leu15]-Orexin B
References are publications that support the biological activity of the product.
Asahi et al (2003) Development of an orexin-2 receptor selective agonist, [Ala11D-Leu15]orexin-B. Bioorg.Med.Chem.Lett. 13 111 PMID: 12467628
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Keywords: [Ala11,D-Leu15]-Orexin B, [Ala11,D-Leu15]-Orexin B supplier, Potent, selective, OX2, receptor, agonists, Orexin2, Receptors, [Ala11D-Leu15]-OrexinB, Receptor, 2142, Tocris Bioscience
4 Citations for [Ala11,D-Leu15]-Orexin B
Citations are publications that use Tocris products. Selected citations for [Ala11,D-Leu15]-Orexin B include:
Moore et al (2014) Effects of orexin 2 receptor activation on apnea in the C57BL/6J mouse. Respir Physiol Neurobiol 200 118 PMID: 24929062
Malherbe et al (2009) Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. Br J Pharmacol 156 1326 PMID: 19751316
Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004 PMID: 22652455
Shahid et al (2012) Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex. Br J Pharmacol 165 2292 PMID: 21951179
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