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Description: Potent GABAA antagonist; β1-subunit selective
Chemical Name: Salicylidene salicylhydrazide
Biological Activity for SCS
SCS is a potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 values are 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively). May bind allosterically to a novel site on GABAA receptor.
Technical Data for SCS
| M. Wt | 256.26 |
| Formula | C14H12N2O3 |
| Storage | Store at RT |
| CAS Number | 3232-36-8 |
| PubChem ID | 252156309 |
| InChI Key | OMCYEZUIYGPHDJ-OQLLNIDSSA-N |
| Smiles | OC1=CC=CC=C1\C=N\NC(=O)C1=CC=CC=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SCS
References for SCS
References are publications that support the biological activity of the product.
Thompson et al (2004) Salicylidene salicylhydrazide, a selective inhibitor of β1-containing GABAA receptors. Br.J.Pharmacol. 142 97 PMID: 15100159
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Keywords: SCS, SCS supplier, Selective, GABAA, receptor, antagonists, beta1-subunit-selective, Receptors, 2143, Tocris Bioscience
2 Citations for SCS
Citations are publications that use Tocris products. Selected citations for SCS include:
Limon et al (2012) Loss of functional GABA(A) receptors in the Alzheimer diseased brain. J Leukoc Biol 109 10071 PMID: 22691495
Villumsen et al (2015) Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 16 8 PMID: 25887256
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.