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Submit ReviewDibutyryl-cAMP, sodium salt
Description: Cell-permeable cAMP analog
Chemical Name: N6,O2'-Dibutyryl adenosine 3',5'-cyclic monophosphate sodium salt
Purity: ≥98% (HPLC)
Biological Activity for Dibutyryl-cAMP, sodium salt
Dibutyryl-cAMP sodium salt is a cell-permeable analog of cAMP that activates cAMP-dependent protein kinases and is a phosphodiesterase inhibitor. Combined with other reagents, dibutyryl-cAMP promotes differentiation of neural stem/progenitor cells (NSPCs) and other cell lines and increases survival rates of NSPCs and differentiation into neurons in vivo. Promotes neurite outgrowth in cell cultures. Dibutyryl-cAMP has anti-inflammatory activity and is used to promote wound healing. Choline acetyltransferase and vesicular acetylcholine transporter mRNA are increased in cells treated with dibutyryl-cAMP.
Compound Libraries for Dibutyryl-cAMP, sodium salt
Dibutyryl-cAMP, sodium salt is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for Dibutyryl-cAMP, sodium salt
| M. Wt | 491.37 |
| Formula | C18H23N5NaO8P |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 16980-89-5 |
| PubChem ID | 23663967 |
| InChI Key | KRBZRVBLIUDQNG-JBVYASIDSA-M |
| Smiles | [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](OC(=O)CCC)[C@@H](O2)N1C=NC2=C1N=CN=C2NC(=O)CCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Dibutyryl-cAMP, sodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 49.14 | 100 | |
| DMSO | 49.14 | 100 |
Preparing Stock Solutions for Dibutyryl-cAMP, sodium salt
The following data is based on the product molecular weight 491.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.04 mL | 10.18 mL | 20.35 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.07 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.04 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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Product Datasheets for Dibutyryl-cAMP, sodium salt
References for Dibutyryl-cAMP, sodium salt
References are publications that support the biological activity of the product.
Carranza et al (1998) Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 511 235 PMID: 9679177
Hei et al (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs Mol.Pharmacol. 39 233 PMID: 1847496
Imamura et al (1998) Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes. Proc.Natl.Acad.Sci.U.S.A. 95 6139 PMID: 9600931
Xia et al (2016) Transcriptional comparison of human induced and primary midbrain DArgic neurons. Sci.Rep. 6 20270 PMID: 26842779
Kim et al (2011) Effects of dibutyryl cyclic-AMP on survival and neuronal differentiation of neural stem/progenitor cells transplanted into spinal cord injured rats. PLoS One 6 PMID: 21738784
If you know of a relevant reference for Dibutyryl-cAMP, sodium salt, please let us know.
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Keywords: Dibutyryl-cAMP, sodium salt, Dibutyryl-cAMP, sodium salt supplier, Cell-permeable, cAMP, Cyclic, adenosines, Monophosphate, Inositol, Signaling, Signalling, cAMP-dependent, protein, kinase, PKA, Kinase, A, differentiation, bucladesine, phosphodiesterase, ESCs, and, iPSC, Neural, Stem, Cells, 1141, Tocris Bioscience
4 Citations for Dibutyryl-cAMP, sodium salt
Citations are publications that use Tocris products. Selected citations for Dibutyryl-cAMP, sodium salt include:
Park et al (2005) Activation of inward rectifier K+ channels by hypoxia in rabbit coronary arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 289 H2461 PMID: 16284107
Kelm et al (2008) The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons. J Neurophysiol 100 3417 PMID: 18945815
Telpoukhovskaia et al (2020) Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia. Sci Rep 10
Sarkar et al (2018) Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Cell Stem Cell 22 684 PMID: 29727680
Do you know of a great paper that uses Dibutyryl-cAMP, sodium salt from Tocris? Please let us know.
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