Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMDL 28170
Description: Potent, selective calpain and cathepsin B inhibitor
Chemical Name: N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal
Purity: ≥95% (HPLC)
Biological Activity for MDL 28170
Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.
Technical Data for MDL 28170
| M. Wt | 382.45 |
| Formula | C22H26N2O4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 88191-84-8 |
| PubChem ID | 11199915 |
| InChI Key | NGBKFLTYGSREKK-ANYOKISRSA-N |
| Smiles | O=C(N[C@@H]([C@H](C)C)C(NC(CC2=CC=CC=C2)C([H])=O)=O)OCC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MDL 28170
References for MDL 28170
References are publications that support the biological activity of the product.
Chen et al (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 769 188 PMID: 9374290
Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17 PMID: 9637399
Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150 PMID: 1877091
Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960 PMID: 17600513
View Related Products by Target
View Related Products by Product Action
Keywords: MDL 28170, MDL 28170 supplier, Potent, selective, calpain, cathepsin, B, inhibitors, inhibits, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, MDL28170, Calpains, Cathepsin, 1146, Tocris Bioscience
3 Citations for MDL 28170
Citations are publications that use Tocris products. Selected citations for MDL 28170 include:
Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. J Neurosci 6 9173 PMID: 25823819
Zechel et al (2016) Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons. Elife 5 PMID: 27935475
Schubert et al (2014) Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol 128 835 PMID: 25341622
Reviews for MDL 28170
There are currently no reviews for this product. Be the first to review MDL 28170 and earn rewards!
Have you used MDL 28170?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image