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Submit ReviewAngiotensin II
Description: Potent vasoconstrictor peptide
Purity: ≥95% (HPLC)
Biological Activity for Angiotensin II
Angiotensin II is a endogenous potent vasoconstrictor peptide; endogenous substrate for ACE2. Stimulates the synthesis and release of aldosterone.
Technical Data for Angiotensin II
| M. Wt | 1046.2 |
| Formula | C50H71N13O12 |
| Sequence | DRVYIHPF |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 4474-91-3 |
| PubChem ID | 172198 |
| InChI Key | CZGUSIXMZVURDU-JZXHSEFVSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Angiotensin II
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Angiotensin II
References for Angiotensin II
References are publications that support the biological activity of the product.
Clayton et al (1998) Effects of prostaglandins and nitric oxide on the renal effects of angiotensin II in the anaesthetised rat. Br.J.Pharmacol. 124 1467 PMID: 9723960
Mosequeda-Garcia et al (1990) Cardiovascular effects of microinjection of angiotensin II in the brainstem of renal hypertensive rats. J.Pharmacol.Exp.Ther. 255 374 PMID: 2213569
Potts et al (1999) Activation of brain neurons by circulating angiotensin II: direct effects and baroreceptor-mediated secondary effects. Neuroscience 90 581 PMID: 10215161
If you know of a relevant reference for Angiotensin II, please let us know.
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Keywords: Angiotensin II, Angiotensin II supplier, Potent, vasoconstrictor, peptide, AT, Receptors, Non-Selective, Angiotensin, AngiotensinII, Non-selective, ACE2, 1158, Tocris Bioscience
10 Citations for Angiotensin II
Citations are publications that use Tocris products. Selected citations for Angiotensin II include:
Rodrigues-Diez et al (2015) The C-terminal module IV of connective tissue growth factor, through EGFR/Nox1 signaling, activates the NF-κB pathway and proinflammatory factors in vascular smooth muscle cells. Hum Mol Genet 22 29 PMID: 25065408
Klingerman et al (2016) Acute Metabolic Effects of olanz. Depend on Dose and Injection Site. Dose Response 13 1559325815618910 PMID: 26740814
Nistala et al (2010) Differential effects of alendr. and los. therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome. J Mol Endocrinol 19 4790 PMID: 20871099
Felizola et al (2014) PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues. Proc Natl Acad Sci U S A 52 159 PMID: 24403568
Vinciguerra et al (2009) Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging (Albany NY) 2 43 PMID: 20228935
Schéle et al (2017) Central administration of ghrelin induces conditioned avoidance in rodents. Eur Neuropsychopharmacol 27 809 PMID: 28647450
Bake et al (2017) Acute ghrelin changes food preference from a high-fat diet to chow during binge-like eating in rodents. J Neuroendocrinol 29 PMID: 28219000
Zheng et al (2017) Gastrodin Inhibits Store-Operated Ca(2+) Entry and Alleviates Cardiac Hypertrophy. Front Pharmacol 8 222 PMID: 28487655
Weng (2018) Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER Ca2+ leakage channel Sec61? in mouse hearts. Cell Death Dis 9 612 PMID: 29795235
Bake et al (2018) Ghrelin's effects on food motivation in rats are not limited to palatable foods. J Neuroendocrinol e12665 PMID: 30525248
Do you know of a great paper that uses Angiotensin II from Tocris? Please let us know.
Reviews for Angiotensin II
Average Rating: 5 (Based on 1 Review.)
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Angiotensin II-induced H9c2 cell hypertrophy in vitro study.
By
YANCHUN XU on 01/05/2018
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: H9C2
We used this product to treat H9C2 cells to induce the cell hypetrophy and investigate the cell signalling pathway
