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Submit ReviewNTNCB hydrochloride
Description: Potent and selective non-peptidic NPY Y5 antagonist
Chemical Name: 2-Nitro-N-[[trans-4-[[[(1,2,3,4-tetrahydro-2-naphthalenyl)methyl]amino]methyl]cyclohexyl]methyl]benzenesulfonamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for NTNCB hydrochloride
NTNCB hydrochloride is a selective, non-peptide competitive NPY Y5 antagonist. Ki values are 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).
Technical Data for NTNCB hydrochloride
| M. Wt | 508.07 |
| Formula | C25H33N3O4S.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 191931-56-3 |
| PubChem ID | 124081021 |
| InChI Key | BKCQHNDMUNWNQC-GMIOCVINSA-N |
| Smiles | O=S(NC[C@@H](CC3)CC[C@H]3CNCC2CCC1=CC=CC=C1C2)(C4=C([N+]([O-])=O)C=CC=C4)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NTNCB hydrochloride
References for NTNCB hydrochloride
References are publications that support the biological activity of the product.
Islam et al (2002) Discovery of potent and selective small molecule NPY Y5 receptor antagonists. Bioorg.Med.Chem.Lett. 12 1767 PMID: 12067557
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Keywords: NTNCB hydrochloride, NTNCB hydrochloride supplier, Potent, selective, non-peptidic, Y5, antagonists, Neuropeptide, Y, Receptors, NPY, neuropeptides, 2155, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.