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Description: Caspase-3 inhibitor
Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Gln-Met-Asp(OMe)-fluoromethylketone
Biological Activity for Z-DQMD-FMK
Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
Technical Data for Z-DQMD-FMK
| M. Wt | 685.72 |
| Formula | C29H40FN5O11S |
| Sequence |
DQMD (Modifications: Asp-1 = Z-Asp(OMe), Asp-4 = (OMe)-fluoromethylketone) |
| Storage | Desiccate at -20°C |
| PubChem ID | 644197 |
| InChI Key | QFITYVNVMNJELE-TUFLPTIASA-N |
| Smiles | [H]N([C@@H](CC(=O)OC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Z-DQMD-FMK
References for Z-DQMD-FMK
References are publications that support the biological activity of the product.
Izban et al (2001) Characterization of NF-κB expression in Hodgkin's disease: inhibition of constitutively expressed NF-κB results in spontaneous caspase-independent apoptosis in Hodgkin and Reed-Sternberg cells. Mod.Pathol. 14 297 PMID: 11301346
Bang et al (2004) Differential response to MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents. Biochem.Pharmacol. 68 659 PMID: 15276073
Chou et al (2004) Alterations in protein kinase C activity and processing during zinc deficiency-induced cell death. Biochem.J. 383 63 PMID: 15198639
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Keywords: Z-DQMD-FMK, Z-DQMD-FMK supplier, Caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2168, Tocris Bioscience
1 Citation for Z-DQMD-FMK
Citations are publications that use Tocris products. Selected citations for Z-DQMD-FMK include:
Allam et al (2018) HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation. PLoS One 13 e0194185 PMID: 29601578
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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