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Description: Irreversible caspase-6 inhibitor
Chemical Name: Benzyloxycarbonyl-Val-Glu(OMe)-Ile-Asp(OMe)-fluoromethylketone
Biological Activity for Z-VEID-FMK
Irreversible caspase-6 inhibitor. Inhibits nuclear protein cleavage in Fas antibody-treated HeLa cells.
Technical Data for Z-VEID-FMK
| M. Wt | 652.72 |
| Formula | C31H45FN4O10 |
| Sequence |
VEID (Modifications: Val-1 = Z-Val, Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone) |
| Storage | Store at -20°C |
| Smiles | [H]N([C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Z-VEID-FMK
References for Z-VEID-FMK
References are publications that support the biological activity of the product.
Abdo et al (2003) Role of tumor necrosis factor-alpha and the modulating effect of the caspases in rat corpus luteum apoptosis. Biol.Reprod. 68 1241 PMID: 12606464
Nyormoi et al (2003) Sequence-based discovery of a synthetic peptide inhibitor of caspase 6. Apoptosis 8 371 PMID: 12815280
Taimen and Kallajoki (2003) NuMA and nuclear lamins behave differently in Fas-mediated apoptosis. J.Cell Sci. 116 571 PMID: 12508117
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Keywords: Z-VEID-FMK, Z-VEID-FMK supplier, Irreversible, caspase-6, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2169, Tocris Bioscience
Citations for Z-VEID-FMK
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