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Submit ReviewGhrelin (human)
Description: Endogenous ghrelin receptor agonist
Purity: ≥95% (HPLC)
Biological Activity for Ghrelin (human)
Ghrelin (human) is an endogenous agonist peptide for the ghrelin receptor (GHS-R1a). Produced mainly by the stomach, it stimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production.
Licensing Information
This peptide is distributed under license from Dr. Kangawa
Technical Data for Ghrelin (human)
| M. Wt | 3370.9 |
| Formula | C149H249N47O42 |
| Sequence |
GSSFLSPEHQRVQQRKESKKPPAKLQPR (Modifications: Ser-3 = Ser(n-octanoyl)) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 258279-04-8 |
| PubChem ID | 16133832 |
| InChI Key | GNKDKYIHGQKHHM-RJKLHVOGSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](COC(=O)CCCCCCC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ghrelin (human)
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for Ghrelin (human)
References for Ghrelin (human)
References are publications that support the biological activity of the product.
Inui (2001) Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat.Rev.Neurosci. 2 551 PMID: 11483998
Kojima et al (1999) Ghrelin is growth-hormone-releasing acylated peptide from stomach. Nature 402 656 PMID: 10604470
Tolle et al (2001) In vivo and in vitro effects of ghrelin/motilin-related peptide on GH secretion in the rat. Neuroendocrinology 73 54 PMID: 11174017
If you know of a relevant reference for Ghrelin (human), please let us know.
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Keywords: Ghrelin (human), Ghrelin (human) supplier, Endogenous, ghrelin, receptor, agonists, GHS-R1a, Receptors, Growth, Hormone, Secretagog, Receptor, 1a, peptides, acylated, Ghrelin, 1463, Tocris Bioscience
3 Citations for Ghrelin (human)
Citations are publications that use Tocris products. Selected citations for Ghrelin (human) include:
Bake et al (2018) Ghrelin's effects on food motivation in rats are not limited to palatable foods. J Neuroendocrinol e12665 PMID: 30525248
Bake et al (2017) Acute ghrelin changes food preference from a high-fat diet to chow during binge-like eating in rodents. J Neuroendocrinol 29 PMID: 28219000
Rodríguez et al (2009) Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. Sci Signal 33 541 PMID: 19238155
Do you know of a great paper that uses Ghrelin (human) from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.