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Submit ReviewNeuropeptide W-23 (human)
Description: Endogenous NPBW1 and NPBW2 receptor agonist
Alternative Names: NPW-23
Biological Activity for Neuropeptide W-23 (human)
Endogenous peptide agonist of Neuropeptide B/Neuropeptide W receptors NPBW1 and NPBW2 (previously known as GPR7 and GPR8 respectively). Increases food intake following injection into the paraventricular nucleus.
Technical Data for Neuropeptide W-23 (human)
| M. Wt | 2584.03 |
| Formula | C119H183N35O28S |
| Sequence | WYKHVASPRYHTVGRAAGLLMGL |
| Storage | Desiccate at -20°C |
| CAS Number | 383415-79-0 |
| PubChem ID | 16209885 |
| InChI Key | AKMMHLDUORFPQZ-BKMDBHAQSA-N |
| Smiles | [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Neuropeptide W-23 (human)
References for Neuropeptide W-23 (human)
References are publications that support the biological activity of the product.
Shimomura et al (2002) Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. J.Biol.Chem. 277 35826 PMID: 12130646
Brezillon et al (2003) Identification of natural ligands for the orphan G prortein-coupled receptors GPR7 and GPR8. J.Biol.Chem. 278 776 PMID: 12401809
Levine et al (2005) Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake. Am.J.Physiol.Regul.Integr.Comp.Physiol. 288 R1727 PMID: 15886360
Hondo et al (2008) The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion. Results Probl.Cell Differ. 46 239 PMID: 18204824
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Keywords: Neuropeptide W-23 (human), Neuropeptide W-23 (human) supplier, Endogenous, NPBW1, NPBW2, agonists, Receptors, Neuropeptides, B, W, NPW23, GPR7, GPR8, NPW-23, Other, Peptide, 3009, Tocris Bioscience
Citations for Neuropeptide W-23 (human)
Citations are publications that use Tocris products.
Currently there are no citations for Neuropeptide W-23 (human).
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.