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Submit ReviewPACAP 1-27
Description: Potent stimulator of adenylyl cyclase
Alternative Names: Pituitary Adenylate Cyclase-Activating Polypeptide 1-27
Purity: ≥95% (HPLC)
Biological Activity for PACAP 1-27
PACAP 1-27 is an endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP). Potently stimulates adenylyl cyclase.
Technical Data for PACAP 1-27
| M. Wt | 3147.6 |
| Formula | C142H224N40O39S |
| Sequence |
HSDGIFTDSYSRYRKQMAVKKYLAAVL (Modifications: Leu-27 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 127317-03-7 |
| PubChem ID | 16137193 |
| InChI Key | RZGBUJXSKLDAFE-QYHUGZLJSA-N |
| Smiles | [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PACAP 1-27
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for PACAP 1-27
References for PACAP 1-27
References are publications that support the biological activity of the product.
Hirose et al (1997) Pituitary adenylate cyclase-activating polypeptide-27 causes a biphasic chronotropic effect and atrial fibrillation in autonomically decentralized, anaesthetized dogs. J.Pharmacol.Exp.Ther. 283 478 PMID: 9353360
Michel et al (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143 PMID: 9549761
Rawlings et al (1994) Pituitary adenylate cyclase-activating polypeptide increase [Ca2+]i in rat gonadotrophs through an inositol trisphosphate-dependent mechanism. J.Biol.Chem. 269 5680 PMID: 7907085
If you know of a relevant reference for PACAP 1-27, please let us know.
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Keywords: PACAP 1-27, PACAP 1-27 supplier, Potently, stimulates, adenylyl, cyclases, stimulator, adenylate, Inositol, cAMP, Signaling, Signalling, Pituitary, Adenylate, Activating, Peptide, Receptors, PAC1, PACAP127, Cyclase-Activating, Polypeptide, 1-27, PACAP, Adenylyl, Cyclase, 1183, Tocris Bioscience
1 Citation for PACAP 1-27
Citations are publications that use Tocris products. Selected citations for PACAP 1-27 include:
Rivell et al (2019) Sonic hedgehog expression in the postnatal brain. Biol Open 8 PMID: 30837226
Do you know of a great paper that uses PACAP 1-27 from Tocris? Please let us know.
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