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Submit ReviewAmthamine dihydrobromide
Description: Highly selective standard H2 agonist
Chemical Name: 2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide
Purity: ≥99% (HPLC)
Biological Activity for Amthamine dihydrobromide
Amthamine dihydrobromide is a highly selective H2 agonist, slightly more potent than histamine itself. Only a weak antagonist at H3 and has no activity at H1 receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro.
Technical Data for Amthamine dihydrobromide
| M. Wt | 319.06 |
| Formula | C6H11N3S.2HBr |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 142457-00-9 |
| PubChem ID | 16218912 |
| InChI Key | XFXNNOPUDSFVJE-UHFFFAOYSA-N |
| Smiles | Br.Br.CC1=C(CCN)SC(N)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Amthamine dihydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.91 | 100 |
Preparing Stock Solutions for Amthamine dihydrobromide
The following data is based on the product molecular weight 319.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.67 mL | 31.34 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.27 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets for Amthamine dihydrobromide
References for Amthamine dihydrobromide
References are publications that support the biological activity of the product.
Coruzzi et al (1993) The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion. Naunyn Schmiedebergs Arch.Pharmacol. 348 77 PMID: 8377843
Eriks et al (1992) Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole. J.Med.Chem. 35 3239 PMID: 1507209
Jarajapu et al (2006) Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP. Eur.J.Pharmacol. 547 116 PMID: 16920098
Poli et al (1993) In vitro cardiac pharmacology of the new histamine H2 receptor agonist amthamine; comparisons with histamine and dimaprit. Agents Actions 40 44 PMID: 8147269
If you know of a relevant reference for Amthamine dihydrobromide, please let us know.
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Keywords: Amthamine dihydrobromide, Amthamine dihydrobromide supplier, selective, H2, agonists, Receptors, Histamine, histaminergic, 0668, Tocris Bioscience
4 Citations for Amthamine dihydrobromide
Citations are publications that use Tocris products. Selected citations for Amthamine dihydrobromide include:
Chigaev et al (2011) Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. J Biol Chem 286 20375 PMID: 21515675
Copsel et al (2011) Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation. J Biol Chem 286 6979 PMID: 21205825
Saligrama et al (2014) Histamine H2 receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis. FASEB J 28 1898 PMID: 24371118
Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.