Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNSC 146109 hydrochloride
Description: Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
Chemical Name: (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
Purity: ≥97% (HPLC)
Biological Activity for NSC 146109 hydrochloride
NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.
Technical Data for NSC 146109 hydrochloride
| M. Wt | 316.85 |
| Formula | C17H16N2S.HCl |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 59474-01-0 |
| PubChem ID | 5458312 |
| InChI Key | VIBMUYOXJUCEMA-UHFFFAOYSA-N |
| Smiles | N=C(N)SCC1=C(C=CC=C3)C3=C(C)C2=C1C=CC=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NSC 146109 hydrochloride
References for NSC 146109 hydrochloride
References are publications that support the biological activity of the product.
Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285 PMID: 12676586
Berkson et al (2005) Pilot screening programme for small molecule activators of p53. Int.J.Cancer 115 701 PMID: 15729694
View Related Products by Target
View Related Products by Product Action
Keywords: NSC 146109 hydrochloride, NSC 146109 hydrochloride supplier, Cell-permeable, genotype-selective, antitumor, agent, activates, p53-dependent, transcription, p53, Transcription, Factors, MDM2, p14ARF, NSC146109, hydrochloride, 2185, Tocris Bioscience
1 Citation for NSC 146109 hydrochloride
Citations are publications that use Tocris products. Selected citations for NSC 146109 hydrochloride include:
Calo et al (2018) Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature 554 112 PMID: 29364875
Reviews for NSC 146109 hydrochloride
Average Rating: 4 (Based on 1 Review.)
Have you used NSC 146109 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
p53 activation.
By
Anonymous on 02/29/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: hela
p53-mediated apoptosis after treatment with NSC146109 for 12–16 hours
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Pathways for NSC 146109 hydrochloride
