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Submit ReviewRo 0437626
Description: Selective P2X1 antagonist
Chemical Name: N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for Ro 0437626
Ro 0437626 is a selective P2X1 purinergic receptor antagonist (IC50 = 3 μM) that displays > 30-fold selectivity over P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).
Technical Data for Ro 0437626
| M. Wt | 525.66 |
| Formula | C27H35N5O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 134362-79-1 |
| PubChem ID | 11663667 |
| InChI Key | JHRSGCIIDRWHCD-UARRHKHWSA-N |
| Smiles | O[C@@H](C1CC1)[C@H](O)[C@H](CC2CCCCC2)NC([C@@H](CC3=CSC=N3)NC(C(N4)=NC5=C4C=CC=C5)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ro 0437626
References for Ro 0437626
References are publications that support the biological activity of the product.
Jaime-Figueroa et al (2005) Discovery and synthesis of a novel and selective drug-like P2X1 antagonist. Bioorg.Med.Chem.Lett. 15 3292 PMID: 15927468
King et al (2004) Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br.J.Pharmacol. 142 519 PMID: 15148261
Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132 PMID: 16465177
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Keywords: Ro 0437626, Ro 0437626 supplier, Selective, P2X1, antagonists, P2X, Receptors, Purinergic, purinoceptors, Ro0437626, 2188, Tocris Bioscience
Citations for Ro 0437626
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.