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Submit ReviewPD 160170
Description: Selective non-peptide NPY Y1 receptor antagonist
Chemical Name: 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine
Purity: ≥98% (HPLC)
Biological Activity for PD 160170
Potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC50 = 8.2 nM).
Technical Data for PD 160170
| M. Wt | 371.41 |
| Formula | C18H17N3O4S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 181468-88-2 |
| PubChem ID | 9820766 |
| InChI Key | YUVNGBZROXQYQH-UHFFFAOYSA-N |
| Smiles | CC(C)C1=CC=CC=C1S(=O)(=O)C1=CC(N)=C2N=CC=CC2=C1[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PD 160170
References for PD 160170
References are publications that support the biological activity of the product.
Wright et al (1996) 8-Amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists. Bioorg.Med.Chem.Lett. 6 1809
Wielgosz-Collin et al (2002) 8-Amino-5-nitro-6-phenoxyquinolines:potential non-peptidic neuropeptide Y receptor ligands. J.Enz.Inhib.Med.Chem. 17 449
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Keywords: PD 160170, PD 160170 supplier, Selective, non-peptide, NPY, Y1, antagonists, Neuropeptide, Y, Receptors, PD160170, neuropeptides, 2200, Tocris Bioscience
2 Citations for PD 160170
Citations are publications that use Tocris products. Selected citations for PD 160170 include:
Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Physiol Rep 488 172 PMID: 22801496
Zambrano et al (2015) Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure. Pharmacol Res Perspect 3 e00111 PMID: 25729578
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.