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Submit ReviewD-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt
Description: Ca2+ mobilizing second messenger
Biological Activity
D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt is an important second messenger involved in Ca2+ mobilization from intracellular stores (EC50 = 0.1 μM). Formed from the enzymatic hydrolysis of phosphatidyl inositol-4,5-bisphosphate.
Technical Data
| M. Wt | 648.64 |
| Formula | C6H9O15P3.K6 |
| Storage | Store at -20°C |
| CAS Number | 103476-24-0 |
| PubChem ID | 16219525 |
| InChI Key | DVOPWCOAGWTTEN-PPKFVSOLSA-H |
| Smiles | [K+].[K+].[K+].[K+].[K+].[K+].O[C@@H]1[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](O)[C@@H]1OP([O-])([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Joseph et al (1984) myo-Inositol 1,4,5-trisphosphate. J.Biol.Chem. 259 3077 PMID: 6607924
Murphy et al (1996) Enantiomers of myo-inositol-1,3,4-trisphosphate and myo-inositol-1,4,6-trisphosphate: stereospecific recognition by cerebellar and platelet myo-inositol-1,4,5-trisphosphate receptors. Mol.Pharmacol. 50 1223 PMID: 8913354
Wilcox et al (1998) New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor. TiPS 19 467 PMID: 9850611
If you know of a relevant reference for D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt, please let us know.
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Keywords: D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt, D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt supplier, Ca2+, mobilizing, mobilising, second, messenger, inositol, lipids, D-myo-Inositol145-trisphosphate, hexapotassium, salt, Inositol, Lipids, 1482, Tocris Bioscience
1 Citation for D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt
Citations are publications that use Tocris products. Selected citations for D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt include:
Li et al (2016) Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated Ins secretion. Cell Death Dis 7 e2275 PMID: 27336719
Do you know of a great paper that uses D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt from Tocris? Please let us know.
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