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Description: Endogenous lipid; potentiates effects of endovanilloids at TRPV1 receptors
Alternative Names: N-Palmitoyldopamine
Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]hexadecanamide
Purity: ≥98% (HPLC)
Biological Activity for PALDA
Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA; lowers EC50 from ~ 90 to ~ 30 nM.
Technical Data for PALDA
| M. Wt | 391.59 |
| Formula | C24H41NO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 136181-87-8 |
| PubChem ID | 16759163 |
| InChI Key | TWJJFOWLTIEYFO-UHFFFAOYSA-N |
| Smiles | CCCCCCCCCCCCCCCC(=O)NCCC1=CC(O)=C(O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PALDA
References for PALDA
References are publications that support the biological activity of the product.
Chu et al (2003) N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099
De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acylDAs on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251 PMID: 15289293
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Keywords: PALDA, PALDA supplier, Endogenous, lipid, potentiates, effects, endovanilloids, TRPV1, receptors, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, N-Palmitoyldopamine, 2203, Tocris Bioscience
Citations for PALDA
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