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Description: Disrupts interaction between GluK2 and PSD-95 PDZ1 domain
Biological Activity for PDZ1 Domain inhibitor peptide
PDZ1 Domain inhibitor peptide is a novel cyclic peptide that disrupts interaction between GluK2 (formerlyy GluR6) and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluK2 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data for PDZ1 Domain inhibitor peptide
| M. Wt | 819.95 |
| Formula | C38H61N9O11 |
| Sequence |
YKKTEAV (Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6)) |
| Storage | Desiccate at -20°C |
| CAS Number | 1315378-73-4 |
| PubChem ID | 90488746 |
| InChI Key | XXRRADBJCXMGOW-RMLJCASOSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PDZ1 Domain inhibitor peptide
References for PDZ1 Domain inhibitor peptide
References are publications that support the biological activity of the product.
Piserchio et al (2004) Targeting specific PDZ domains of PSD-95: structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem.Biol. 11 469 PMID: 15123241
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Keywords: PDZ1 Domain inhibitor peptide, PDZ1 Domain inhibitor peptide supplier, Disrupts, interaction, between, GluR6, PSD-95, PDZ1, domain, Glutamate, Kainate, Receptors, iGluR, Ionotropic, GluK2, 2207, Tocris Bioscience
Citations for PDZ1 Domain inhibitor peptide
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Currently there are no citations for PDZ1 Domain inhibitor peptide.
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