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Submit ReviewD-Aspartic acid
Description: NMDA agonist
Chemical Name: D-Aminosuccinic acid
Biological Activity for D-Aspartic acid
D-Aspartic acid is an endogenous NMDA receptor agonist with similar activity to the L-isomer. Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland.
L-isomer also available.
Technical Data for D-Aspartic acid
| M. Wt | 133.1 |
| Formula | C4H7NO4 |
| Storage | Store at RT |
| CAS Number | 1783-96-6 |
| PubChem ID | 83887 |
| InChI Key | CKLJMWTZIZZHCS-UWTATZPHSA-N |
| Smiles | N[C@@]([H])([C@](O)=O)CC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for D-Aspartic acid
References for D-Aspartic acid
References are publications that support the biological activity of the product.
Hashimoto et al (1997) Free D-aspartate and D-serine in the mammalian brain and periphery. Prog.Neurobiol. 53 325 PMID: 9247969
Ishio et al (1998) D-Aspartate modulates melatonin synthesis in rat pinealocytes. Neurosci.Lett. 249 143 PMID: 9682837
Olverman et al (1988) Structure/activity relations of NMDA receptor ligands as studied by their inhibition of 3H-D-AP5 binding in rat brain membranes. Neuroscience 26 17 PMID: 2901691
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Keywords: D-Aspartic acid, D-Aspartic acid supplier, NMDA, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Amino, Acids, 0213, Tocris Bioscience
1 Citation for D-Aspartic acid
Citations are publications that use Tocris products. Selected citations for D-Aspartic acid include:
Cai and Ford (2018) DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate. Cell Rep 25 3148 PMID: 30540946
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