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Submit ReviewDCG IV
Description: Highly potent group II mGlu agonist; also NMDA agonist
Chemical Name: (2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine
Purity: ≥98% (HPLC)
Biological Activity for DCG IV
DCG IV is a presynaptic depressant; highly potent agonist for group II mGlu receptors.
Licensing Information
Sold with the permission of Suntory Ltd.
Technical Data for DCG IV
| M. Wt | 203.15 |
| Formula | C7H9NO6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 147782-19-2 |
| PubChem ID | 16758827 |
| InChI Key | MATPZHBYOVDBLI-FKNRSBSYSA-N |
| Smiles | N[C@]([H])(C(O)=O)[C@]1(C([H])(C(O)=O)C([H])1C(O)=O)[H] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DCG IV
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.32 | 100 |
Preparing Stock Solutions for DCG IV
The following data is based on the product molecular weight 203.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.92 mL | 24.61 mL | 49.22 mL |
| 5 mM | 0.98 mL | 4.92 mL | 9.84 mL |
| 10 mM | 0.49 mL | 2.46 mL | 4.92 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.98 mL |
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Product Datasheets for DCG IV
References for DCG IV
References are publications that support the biological activity of the product.
Brabet et al (1998) Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology 37 1043 PMID: 9833633
Cartmell et al (1998) Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes. Br.J.Pharmacol. 123 497 PMID: 9504391
Ishida et al (1993) A novel metabotropic receptor agonist: marked depression of monosynaptic excitation in the isolated rat spinal cord. Br.J.Pharmacol. 109 1169 PMID: 8401927
Ohfune et al (1993) Synthesis of L-2-(2,3-dicarboxycyclopropyl)-glycines. Novel conformationally restricted glutamate analogues. Bioorg.Med.Chem.Lett. 3 15
If you know of a relevant reference for DCG IV, please let us know.
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Keywords: DCG IV, DCG IV supplier, potent, selective, group, II, agonist, NMDA, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, DCGIV, (Metabotropic), 0975, Tocris Bioscience
33 Citations for DCG IV
Citations are publications that use Tocris products. Selected citations for DCG IV include:
Caiati et al (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep 2 285 PMID: 22368777
Vivar et al (2012) Mixed electrical-chemical transmission between hippocampal mossy fibers and pyramidal cells. Eur J Neurosci 35 76 PMID: 22151275
Hagena and Manahan-Vaughan (2010) Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats contributes to the induction of persistent LTD via an adenosine-A1 receptor-regulated mechanism. Cereb Cortex 20 1121 PMID: 19903765
Torborg et al (2010) Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance. J Neurosci 30 15628 PMID: 21084618
Galván et al (2010) Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons. J Neurosci 30 2844 PMID: 20181582
Kim et al (2010) Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals. Nat Commun 30 3870 PMID: 20237257
Ster et al (2011) Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. Proc Natl Acad Sci U S A 108 9993 PMID: 21628565
Miguel Angel Garcia-Bereguiain et al (2016) Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo The Journal of Neuroscience 6 7268 PMID: 27383600
Martin et al (2015) The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus. Elife 4 PMID: 26575286
Maurin et al (2014) Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy. PLoS One 9 e87605 PMID: 24498342
Yin et al (2014) Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34 79 PMID: 24381270
Taman and Ribeiro (2011) Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni. PLoS One 6 e27119 PMID: 22069494
Sydow et al (2011) Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J Neurosci 31 2511 PMID: 21325519
Prickett et al (2011) Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma. Nat Genet 43 1119 PMID: 21946352
Straub et al (2011) Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. Nat Neurosci 14 866 PMID: 21623363
Hashimotodani et al (2017) LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron 95 928 PMID: 28817805
Sun et al (2017) Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall. Neuron 95 656 PMID: 28772124
Wang et al (2008) BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. Proc Natl Acad Sci U S A 28 8677 PMID: 18753368
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Scholler (2017) Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation. Nat Commun 8 1967 PMID: 29213077
Lee and Sherman (2009) Glutamatergic inhibition in sensory neocortex. Cereb Cortex 19 2281 PMID: 19176638
Galván et al (2015) Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons. Neuroscience 290 332 PMID: 25637803
Bagayogo and Dreyfus (2009) Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway. ASN Neuro 1 PMID: 19570026
Suberbielle et al (2015) DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Acta Neuropathol Commun 6 8897 PMID: 26615780
Decker et al (2015) Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation. Cell Rep 3 23 PMID: 25853683
Ben-Simon et al (2015) A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity. J Neurosci 12 396 PMID: 26166572
Kaeser-Woo et al (2013) Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP. J Neurosci 33 9769 PMID: 23739973
Skucas et al (2013) Testosterone depletion in adult male rats increases mossy fiber transmission, LTP, and sprouting in area CA3 of hippocampus. J Neurosci 33 2338 PMID: 23392664
Kim and Tsien (2008) Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation. Neuron 58 925 PMID: 18579082
Suh et al (2008) Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7. Neuron 58 736 PMID: 18549785
Chiu and Castillo (2008) Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology 54 68 PMID: 17706254
Yeckel et al (1999) Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism. Nat Neurosci 2 625 PMID: 10404192
Andrieux et al (2002) The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders. Genes Dev 16 2350 PMID: 12231625
Do you know of a great paper that uses DCG IV from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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