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Submit ReviewBD 1008 dihydrobromide
Description: Potent, selective σ ligand
Chemical Name: N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine dihydrobromide
Biological Activity for BD 1008 dihydrobromide
Potent and selective σ-ligand (Ki against [3H]-(+)-3-PPP = 0.34 nM).
Technical Data for BD 1008 dihydrobromide
| M. Wt | 463.08 |
| Formula | C15H22Cl2N2.2HBr |
| Storage | Store at -20°C |
| CAS Number | 138356-09-9 |
| PubChem ID | 45073417 |
| InChI Key | YTBUMHOSKIAYCZ-UHFFFAOYSA-N |
| Smiles | Br.Br.CN(CCN1CCCC1)CCC1=CC=C(Cl)C(Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BD 1008 dihydrobromide
References for BD 1008 dihydrobromide
References are publications that support the biological activity of the product.
De Costa et al (1992) Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines - structural requirements and binding affinity at the σ receptor. J.Med.Chem. 35 38 PMID: 1310114
Monnet et al (1996) Differentiation of σ ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices. Br.J.Pharmacol. 119 65 PMID: 8872358
Whittemore et al (1997) Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571
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Keywords: BD 1008 dihydrobromide, BD 1008 dihydrobromide supplier, Potent, selective, σ, sigma, ligand, General, Receptors, BD1008, dihydrobromide, Sigma-Related, 0511, Tocris Bioscience
2 Citations for BD 1008 dihydrobromide
Citations are publications that use Tocris products. Selected citations for BD 1008 dihydrobromide include:
Hiranita et al (2013) Stimulants as specific inducers of DA-independentσ agonist self-administration in rats. Neurochem Int 347 42633 PMID: 23908387
Hiranita et al (2011) Decreases in cocaine self-administration with dual inhibition of the DA transporter and σ receptors. J Pharmacol Exp Ther 339 662 PMID: 21859929
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