Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewN1,N11-Diethylnorspermine tetrahydrochloride
Description: Spermine and spermidine acetyltransferase potentiator
Chemical Name: N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediamine tetrahydrochloride
Biological Activity
N1,N11-Diethylnorspermine tetrahydrochloride is a highly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.
Technical Data
| M. Wt | 390.27 |
| Formula | C13H32N4.4HCl |
| Storage | Store at RT |
| CAS Number | 156886-85-0 |
| PubChem ID | 11501988 |
| InChI Key | LAWBSOKBIROCQP-UHFFFAOYSA-N |
| Smiles | CCNCCCNCCCNCCCNCC.Cl.Cl.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 39.03 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 390.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.56 mL | 12.81 mL | 25.62 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets
References
References are publications that support the biological activity of the product.
Bernacki et al (1992) Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 52 2424 PMID: 1568212
Fogel-Petrovic et al (1997) Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 52 69 PMID: 9224814
Libby et al (1991) Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 284 238 PMID: 1989509
Porter et al (1993) Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 53 581 PMID: 8425191
If you know of a relevant reference for N1,N11-Diethylnorspermine tetrahydrochloride, please let us know.
View Related Products by Target
Keywords: N1,N11-Diethylnorspermine tetrahydrochloride, N1,N11-Diethylnorspermine tetrahydrochloride supplier, Spermine, spermidine, N1-acetyltransferase, potentiator, Acyltransferases, Transferases, Enzyme, Substrates, /, Activators, Other, 0468, Tocris Bioscience
1 Citation for N1,N11-Diethylnorspermine tetrahydrochloride
Citations are publications that use Tocris products. Selected citations for N1,N11-Diethylnorspermine tetrahydrochloride include:
Sandusky-Beltran et al (2019) Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response. Alzheimers Res Ther 11 58 PMID: 31253191
Do you know of a great paper that uses N1,N11-Diethylnorspermine tetrahydrochloride from Tocris? Please let us know.
Reviews for N1,N11-Diethylnorspermine tetrahydrochloride
There are currently no reviews for this product. Be the first to review N1,N11-Diethylnorspermine tetrahydrochloride and earn rewards!
Have you used N1,N11-Diethylnorspermine tetrahydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image