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Submit ReviewOctopamine hydrochloride
Discontinued Product
2242 has been discontinued.
View all Adrenergic β<sub>3</sub> Receptors products.
Description: Invertebrate biogenic amine: activates β3 adrenoceptors
Alternative Names: (±)-p-Octopamine,Epirenor,Norfen
Chemical Name: α-(Aminomethyl)-4-hydroxybenzenemethanol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Octopamine hydrochloride
Invertebrate biogenic amine neurotransmitter, related to noradrenalin, that is an adrenoceptor agonist. Stimulates lipolysis in mammalian adipocytes via activation of β3 receptors. Has dual effect on glucose transport in adipocytes: inhibits transport via β3 receptor activation but stimulates transport when oxidized by MAO. Also activates human α2A receptors, inhibiting subsequent cAMP production.
Technical Data for Octopamine hydrochloride
| M. Wt | 189.64 |
| Formula | C8H11NO2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 770-05-8 |
| PubChem ID | 20592 |
| InChI Key | PUMZXCBVHLCWQG-UHFFFAOYSA-N |
| Smiles | Cl.NCC(O)C1=CC=C(O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Octopamine hydrochloride
References for Octopamine hydrochloride
References are publications that support the biological activity of the product.
Airriess et al (1997) Selective inhibition of adenylyl cyclase by octopamine via a human cloned α2A-adrenoceptor. Br.J.Pharmacol. 122 191 PMID: 9313925
Roeder (1999) Octopamine in invertebrates. Prog.Neurobiol. 59 533 PMID: 10515667
Visentin et al (2001) Dual action of octopamine on glucose transport into adipocytes: inhibition via β3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J.Pharmacol.Exp.Ther. 299 96 PMID: 11561068
Carpene et al (1999) Selective activation of β3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn-Schmied.Arch.Pharmacol. 359 310
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1 Citation for Octopamine hydrochloride
Citations are publications that use Tocris products. Selected citations for Octopamine hydrochloride include:
Li et al (2017) Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nat Med 23 733 PMID: 28459438
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.