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Submit ReviewDilazep dihydrochloride
Description: Adenosine uptake inhibitor
Chemical Name: 1,4-bis[3-(3,4,5-Trimethoxybenzoyloxy)propyl]homopiperazine dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Dilazep dihydrochloride
Dilazep dihydrochloride is a coronary and cerebral vasodilator, suppresses the effects of ischemia. Inhibitor of platelet aggregation and of membrane transport of nucleosides. Inhibits adenosine uptake.
Technical Data for Dilazep dihydrochloride
| M. Wt | 677.62 |
| Formula | C31H44N2O10.2HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 20153-98-4 |
| PubChem ID | 29976 |
| InChI Key | VILIWRRWAWKXRW-UHFFFAOYSA-N |
| Smiles | Cl.Cl.COC1=CC(=CC(OC)=C1OC)C(=O)OCCCN1CCCN(CCCOC(=O)C2=CC(OC)=C(OC)C(OC)=C2)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Dilazep dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions for Dilazep dihydrochloride
The following data is based on the product molecular weight 677.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.48 mL | 7.38 mL | 14.76 mL |
| 5 mM | 0.3 mL | 1.48 mL | 2.95 mL |
| 10 mM | 0.15 mL | 0.74 mL | 1.48 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.3 mL |
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Product Datasheets for Dilazep dihydrochloride
References for Dilazep dihydrochloride
References are publications that support the biological activity of the product.
Kawagoe et al (1992) Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study. Naunyn Schmiedebergs Arch.Pharmacol. 345 485 PMID: 1620248
Zhang et al (1991) Dilazep potentation of adenosine-mediated superior mesenteric arterial vasodilation. J.Pharmacol.Exp.Ther. 258 767 PMID: 1890619
If you know of a relevant reference for Dilazep dihydrochloride, please let us know.
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Keywords: Dilazep dihydrochloride, Dilazep dihydrochloride supplier, adenosines, reuptake, inhibitors, inhibits, ENT1, Purine, Transporters, Pyrimidine, Equilibrative, Nucleoside, Monoamine, Neurotransmitter, vasodilator, 0481, Tocris Bioscience
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