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Submit ReviewDimaprit dihydrochloride
Discontinued Product
0506 has been discontinued.
View all Histamine H<sub>2</sub> Receptors products.
Description: Standard H2 selective agonist
Chemical Name: S-(3-Dimethylaminopropyl)isothiourea dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Dimaprit dihydrochloride
Dimaprit dihydrochloride is a selective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).
Technical Data for Dimaprit dihydrochloride
| M. Wt | 234.19 |
| Formula | C6H15N3S.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 23256-33-9 |
| PubChem ID | 90045 |
| InChI Key | DFWCPLGXFMSUCW-UHFFFAOYSA-N |
| Smiles | CN(C)CCCSC(N)=N.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Dimaprit dihydrochloride
References for Dimaprit dihydrochloride
References are publications that support the biological activity of the product.
Durant et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations. Agents Actions 7 39 PMID: 860674
Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169 PMID: 10980276
Paquay et al (1999) Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 127 331 PMID: 10385230
Parsons et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. Agents Actions 7 31 PMID: 871093
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Keywords: Dimaprit dihydrochloride, Dimaprit dihydrochloride supplier, H2, selective, agonists, Receptors, Histamine, histaminergic, 0506, Tocris Bioscience
3 Citations for Dimaprit dihydrochloride
Citations are publications that use Tocris products. Selected citations for Dimaprit dihydrochloride include:
Swartzendruber et al (2012) Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses. Stem Cells Transl Med 188 536 PMID: 22156496
Wang et al (2014) Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line. J Immunol 3 1126 PMID: 25045085
Fei et al (2009) Stimulation of mucosal secretion by lubipro. (SPI-0211) in guinea pig small intestine and colon. Am J Physiol Gastrointest Liver Physiol 296 G823 PMID: 19179625
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.