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Submit Review[Des-octanoyl]-Ghrelin (human)
Description: Major circulating form of ghrelin; devoid of activity at ghrelin receptor but is active in vivo
Biological Activity for [Des-octanoyl]-Ghrelin (human)
[Des-octanoyl]-Ghrelin (human) is a non-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. However, exerts negative inotropic effects in papillary muscle and displays cardioprotective activity. Inhibits cell proliferation in breast and prostate cancer cell lines. Promotes adipogenesis in vivo.
Technical Data for [Des-octanoyl]-Ghrelin (human)
| M. Wt | 3244.51 |
| Formula | C141H235N47O41 |
| Sequence | GSSFLSPEHQRVQQRKESKKPPAKLQPR |
| Storage | Desiccate at -20°C |
| CAS Number | 313951-59-6 |
| PubChem ID | 46236457 |
| InChI Key | BGHSOEHUOOAYMY-JTZMCQEISA-N |
| Smiles | [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for [Des-octanoyl]-Ghrelin (human)
References for [Des-octanoyl]-Ghrelin (human)
References are publications that support the biological activity of the product.
Baldanzi et al (2002) Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J.Cell Biol. 159 1029 PMID: 12486113
Bedendi et al (2003) Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin. Eur.J.Pharmacol. 476 87 PMID: 12969753
Thompson et al (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a GH secretagogue receptor. Endocrinology 145 234 PMID: 14551228
Cassoni et al (2004) Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur.J.Endocrinol. 150 173 PMID: 14763915
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Keywords: [Des-Octanoyl]-Ghrelin (human), [Des-Octanoyl]-Ghrelin (human) supplier, circulating, ghrelin, devoid, activity, receptors, active, in, vivo, GHS-R1a, Growth, Hormone, Secretagog, 1a, Ghrelin, Receptors, 2260, Tocris Bioscience
1 Citation for [Des-octanoyl]-Ghrelin (human)
Citations are publications that use Tocris products. Selected citations for [Des-octanoyl]-Ghrelin (human) include:
Rodríguez et al (2009) Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. FASEB J 33 541 PMID: 19238155
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.