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Submit ReviewTandospirone hydrochloride
Description: Selective 5-HT1A partial agonist
Alternative Names: SM-3997
Chemical Name: (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Tandospirone hydrochloride
Tandospirone hydrochloride is a 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.
Technical Data for Tandospirone hydrochloride
| M. Wt | 419.95 |
| Formula | C21H29N5O2.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 99095-10-0 |
| PubChem ID | 13422623 |
| InChI Key | ACVFJYKNBOHIMH-DPFKZJTMSA-N |
| Smiles | [H][C@]13[C@](C(N(CCCCN4CCN(C5=NC=CC=N5)CC4)C3=O)=O)([H])[C@@H]2CC[C@H]1C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tandospirone hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.99 | 100 | |
| water | 41.99 | 100 |
Preparing Stock Solutions for Tandospirone hydrochloride
The following data is based on the product molecular weight 419.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.91 mL | 23.81 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for Tandospirone hydrochloride
References for Tandospirone hydrochloride
References are publications that support the biological activity of the product.
Hamik et al (1990) Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol.Psychiatry 28 99 PMID: 1974152
Pollard et al (1992) Effects of tandospirone in three behavioral tests for anxiolytics. Eur.J.Pharmacol. 221 297 PMID: 1358655
Matsubara et al (2006) Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-DArgic systems in rats with unilateral 6-hydroxyDA-generated lesions. Brain Res. 1112 126 PMID: 16884702
If you know of a relevant reference for Tandospirone hydrochloride, please let us know.
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Keywords: Tandospirone hydrochloride, Tandospirone hydrochloride supplier, Selective, 5-HT1A, partial, agonists, Serotonin, Receptors, SM3997, SM-3997, 2854, Tocris Bioscience
Citations for Tandospirone hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.