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Description: Inhibits NGF binding to p75NTR and TrkA
Chemical Name: 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
Purity: ≥95% (HPLC)
Biological Activity for Ro 08-2750
Ro 08-2750 is a non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells. Suppresses cancer cell proliferation via regulation of Hippo signaling aand YAP phosphorylation.
Technical Data for Ro 08-2750
| M. Wt | 270.24 |
| Formula | C13H10N4O3 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 37854-59-4 |
| PubChem ID | 17756791 |
| InChI Key | JDEMVNYMYPJJIM-UHFFFAOYSA-N |
| Smiles | CN1C2=CC(C=O)=C(C)C=C2N=C2C(=O)NC(=O)N=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ro 08-2750
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.7 | 10 with gentle warming |
Preparing Stock Solutions for Ro 08-2750
The following data is based on the product molecular weight 270.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37 mL | 185.02 mL | 370.04 mL |
| 0.5 mM | 7.4 mL | 37 mL | 74.01 mL |
| 1 mM | 3.7 mL | 18.5 mL | 37 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
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Product Datasheets for Ro 08-2750
References for Ro 08-2750
References are publications that support the biological activity of the product.
Niederhauser et al (2000) NGF ligand alters NGF signaling via p75NTR and TrkA. J.Neurosci.Res. 61 263 PMID: 10900073
Arkin and Wells (2004) Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat.Rev.Drug Discov. 3 301 PMID: 15060526
Yang et al (2018) NTRK1 is a positive regulator of YAP oncogenic function. Oncogene 38 2778 PMID: 30542115
If you know of a relevant reference for Ro 08-2750, please let us know.
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Keywords: Ro 08-2750, Ro 08-2750 supplier, inhibitors, inhibits, NGF, binding, p75NTR, TrkA, Neurotrophin, Receptors, p75, Trk, Receptor, Tyrosine, Kinases, RTKs, Ro08-2750, YAP, Hippo, signaling, Hippo/Yap, 2272, Tocris Bioscience
Citations for Ro 08-2750
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