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Submit ReviewDIPPA hydrochloride
Description: Selective and irreversible κ antagonist
Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for DIPPA hydrochloride
DIPPA hydrochloride is an an irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.
Technical Data for DIPPA hydrochloride
| M. Wt | 484.87 |
| Formula | C22H23Cl2N3OS.HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 155512-52-0 |
| PubChem ID | 45073425 |
| InChI Key | BNWYENYHNOESCX-ZMBIFBSDSA-N |
| Smiles | ClC1=C(Cl)C=C(CC(N([C@@](CN3CCCC3)([H])C2=CC=CC(N=C=S)=C2)C)=O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DIPPA hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 14.55 | 30 | |
| DMSO | 24.24 | 50 |
Preparing Stock Solutions for DIPPA hydrochloride
The following data is based on the product molecular weight 484.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.12 mL | 20.62 mL | 41.25 mL |
| 2.5 mM | 0.82 mL | 4.12 mL | 8.25 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
| 25 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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Product Datasheets for DIPPA hydrochloride
References for DIPPA hydrochloride
References are publications that support the biological activity of the product.
Chang et al (1994) 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice. J.Med.Chem. 37 1547 PMID: 8201586
Chang et al (1994) κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists. J.Med.Chem. 37 4490 PMID: 7799399
If you know of a relevant reference for DIPPA hydrochloride, please let us know.
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Keywords: DIPPA hydrochloride, DIPPA hydrochloride supplier, Selective, irreversible, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP2, Kappa, Opioid, 0794, Tocris Bioscience
2 Citations for DIPPA hydrochloride
Citations are publications that use Tocris products. Selected citations for DIPPA hydrochloride include:
Carr and Lucki (2010) Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats. Psychopharmacology (Berl) 210 295 PMID: 20369354
Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141
Do you know of a great paper that uses DIPPA hydrochloride from Tocris? Please let us know.
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