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Submit ReviewDoxepin hydrochloride
Discontinued Product
0508 has been discontinued.
View all Histamine H<sub>1</sub> Receptors products.
Description: Highly potent H1 antagonist. Also binds to H4 receptor
Chemical Name: 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Doxepin hydrochloride
Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).
This compound is a mixture of E/Z isomers (ratio: 85:15).
Technical Data for Doxepin hydrochloride
| M. Wt | 315.84 |
| Formula | C19H21NO.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1229-29-4 |
| PubChem ID | 5281088 |
| InChI Key | MHNSPTUQQIYJOT-CULRIWENSA-N |
| Smiles | Cl[H].CN(C)CC\C=C1\C2=C(COC3=C1C=CC=C3)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Doxepin hydrochloride
References for Doxepin hydrochloride
References are publications that support the biological activity of the product.
Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of dox. and other tricyclic antidepressants. Am.J.Psychiatry 140 1006 PMID: 6346907
Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427 PMID: 11179435
Tran et al (1981) [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501 PMID: 7238574
Merck Index 12 3492
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Keywords: Doxepin hydrochloride, Doxepin hydrochloride supplier, potent, H1, antagonists, binds, H4, Receptors, Histamine, histaminergic, 0508, Tocris Bioscience
1 Citation for Doxepin hydrochloride
Citations are publications that use Tocris products. Selected citations for Doxepin hydrochloride include:
Jones et al (2011) Roles of affinity and lipophilicity in the slow kinetics of prostanoid receptor antagonists on isolated smooth muscle preparations. Br J Pharmacol 162 863 PMID: 20973775
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.