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Submit ReviewDTG
Description: High affinity ligand (σ1 = σ2)
Chemical Name: 1,3-Di-(2-tolyl)guanidine
Biological Activity for DTG
Displays high and roughly equal affinity for both σ1 and σ2 receptors.
Technical Data for DTG
| M. Wt | 239.32 |
| Formula | C15H17N3 |
| Storage | Store at RT |
| CAS Number | 97-39-2 |
| PubChem ID | 7333 |
| InChI Key | OPNUROKCUBTKLF-UHFFFAOYSA-N |
| Smiles | CC1=C(NC(=N)NC2=C(C)C=CC=C2)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DTG
References for DTG
References are publications that support the biological activity of the product.
He et al (1993) Synthesis and binding characteristics of potential SPECT imaging agents for σ1 and σ2 binding sites. J.Med.Chem. 36 566 PMID: 8496936
Quirion et al (1992) A proposal for the classification of sigma binding sites. TiPS 13 85 PMID: 1315463
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Keywords: DTG, DTG supplier, High, affinity, ligand, σ1, sigma1, σ2, sigma2, General, Receptors, Sigma-Related, 0841, Tocris Bioscience
2 Citations for DTG
Citations are publications that use Tocris products. Selected citations for DTG include:
Hall et al (2009) Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation. PLoS One 164 470 PMID: 19723565
Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. Neuroscience 350 290 PMID: 24891452
Reviews for DTG
Average Rating: 5 (Based on 1 Review.)
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DTG specifically protects sigma-1 and sigma-2 receptors binding sites..
By
Timur Mavlyutov on 01/06/2018
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: PC12
Photolabeling experiment by Iodoazidofenpropimorph labels multiple receptors, which can be later seen on auto radiogram. Sigma-1 (26kDa) and Sigma-2 (18kDa) receptors were also labeled. To be sure that these two bands are true Sigma-1 and Sigma-2 receptors, photolabeling experiment was performed in the presence of DTG (second lane). Both Sigma-1 and Sigma-2 receptors were selectively protected.
