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Submit ReviewMoxonidine hydrochloride
Description: I1 receptor and α2-adrenoceptor agonist (I1 > α2)
Chemical Name: 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Moxonidine hydrochloride
Mixed I1 imidazoline receptor and α2-adrenergic agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. Centrally acting antihypertensive agent.
Technical Data for Moxonidine hydrochloride
| M. Wt | 278.14 |
| Formula | C9H12ClN5O.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 75536-04-8 |
| PubChem ID | 11231255 |
| InChI Key | ZZPAWQYZQVUVHX-UHFFFAOYSA-N |
| Smiles | Cl.COC1=NC(C)=NC(Cl)=C1NC1=NCCN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Moxonidine hydrochloride
References for Moxonidine hydrochloride
References are publications that support the biological activity of the product.
Schafer et al (2002) Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and α2-adrenoceptors. J.Pharmacol.Exp.Ther. 303 1163 PMID: 12438540
El-Ayoubi et al (2004) Imidazoline receptors but not a2-adrenoceptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment. J.Pharmacol.Exp.Ther. 310 446 PMID: 15075383
Chan et al (2005) Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clon. Neuroscience 132 991 PMID: 15857704
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