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Description: Silent antagonist for putative abnormal-CBD (Cat. No. 1297) receptor
Chemical Name: 1,3-Dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]benzene
Purity: ≥97% (HPLC)
Biological Activity for O-1918
O-1918 is a selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. Inhibits vasodilation and cell migration induced by abnormal-cannabidiol (abn-CBD; Cat. No. 1297).
Licensing Information
Sold under license from the NIH, US patent 60/312,674
Technical Data for O-1918
| M. Wt | 286.41 |
| Formula | C19H26O2 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 536697-79-7 |
| PubChem ID | 40469923 |
| InChI Key | ICHJMVMWPKLUKT-JKSUJKDBSA-N |
| Smiles | COC1=CC(C)=CC(OC)=C1[C@@H]1C=C(C)CC[C@H]1C(C)=C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for O-1918
References for O-1918
References are publications that support the biological activity of the product.
Offertáler et al (2003) Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol.Pharmacol. 63 699 PMID: 12606780
Mo et al (2004) Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go coupled receptor distinct from CB1, CB2 or EDG-1. Eur.J.Pharmacol. 489 21 PMID: 15063151
Hoi and Hiley (2006) Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. Br.J.Pharmacol. 147 560 PMID: 16415907
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Keywords: O-1918, O-1918 supplier, Silent, antagonists, putative, abnormal-CBD, receptor, cannabinoids, Receptors, 0-1918, Other, Cannabinoids, 2288, Tocris Bioscience
3 Citations for O-1918
Citations are publications that use Tocris products. Selected citations for O-1918 include:
Schwartz et al (2018) Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells. Oncotarget 9 34595 PMID: 30349652
Krohn et al (2016) Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment. J Inflamm (Lond) 13 21 PMID: 27418880
Herradón et al (2007) Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. Br J Pharmacol 152 699 PMID: 17704831
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Literature in this Area
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.