Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Reviewα-CGRP (human)
Description: CGRP agonist
Purity: ≥95% (HPLC)
Biological Activity for α-CGRP (human)
α-CGRP (human) is an endogenous calcitonin gene-related peptide receptor (CGRP) agonist. It is a long-lasting vasodilator. α-CGRP (human) also reduces the secretion of both mouse Ins1 and Ins2 proteins and remodels amylin fibrillization in mouse pancreatic β-cells.
Technical Data for α-CGRP (human)
| M. Wt | 3789.33 |
| Formula | C163H267N51O49S2 |
| Sequence |
ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF (Modifications: Phe-37 = C-terminal amide, Disulfide bridge: 2-7) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 90954-53-3 |
| PubChem ID | 44563440 |
| InChI Key | JMJJWZFCOWFIBU-XJVRLEFXSA-N |
| Smiles | [H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for α-CGRP (human)
| Solubility | Soluble to 0.50 mg/ml in water |
Product Datasheets for α-CGRP (human)
References for α-CGRP (human)
References are publications that support the biological activity of the product.
Poyner et al (2002) International union of pharmacology XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol.Revs. 54 233
Gray et al (2021) α-CGRP disrupts amylin fibrillization and regulates insulin secretion: implications on diabetes and migraine. Chem.Sci. 12 5853 PMID: 34168810
Kee et al (2018) The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects. Front Physiol. 9 1249 PMID: 30283343
If you know of a relevant reference for α-CGRP (human), please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: alpha-CGRP (human), alpha-CGRP (human) supplier, CGRP, receptor, agonists, Receptors, calcitonin, amylin, AMY, alpha-CGRP, (human), α-CGRP, a-CGRP, pancreatic, beta-cells, Calcitonin, and, Related, 3012, Tocris Bioscience
Citations for α-CGRP (human)
Citations are publications that use Tocris products.
Currently there are no citations for α-CGRP (human). Do you know of a great paper that uses α-CGRP (human) from Tocris? Please let us know.
Reviews for α-CGRP (human)
Average Rating: 5 (Based on 1 Review.)
Have you used α-CGRP (human)?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Potent CGRP agonist.
By
Anonymous on 09/20/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Hek 293 Cells
in in vitro study (Hek 293 cells), stimulate CGRP Receptor (CLR) on the plasma membrane causing internalization.
Easy to dissolve in DMSO, stock solution concentration 10mM.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.