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Description: Selective PP1 inhibitor
Chemical Name: (1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester
Purity: ≥95% (HPLC)
Biological Activity for Tautomycetin
Tautomycetin is a selective inhibitor of protein phosphatase (PP)1 (IC50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.
Technical Data for Tautomycetin
| M. Wt | 606.75 |
| Formula | C33H50O10 |
| Storage | Desiccate at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 119757-73-2 |
| PubChem ID | 16759609 |
| InChI Key | VAIBGAONSFVVKI-CIFLJJJCSA-N |
| Smiles | O=C(O1)C([C@H](O)CC(O[C@H](C)[C@@H](C)[C@H](O)CC([C@@H](C)[C@@H](O)CC[C@H](C)C[C@@H](C)CC(/C=C(CC)/C=C)=O)=O)=O)=C(C)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tautomycetin
References for Tautomycetin
References are publications that support the biological activity of the product.
Mitsuhashi et al (2001) Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. Biochem.Biophys.Res.Comm. 287 328 PMID: 11554729
Shim et al (2002) Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc.Natl.Acad.Sci.USA. 99 10617 PMID: 12149481
Kim et al (2005) Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells. Transplant Proc. 37 1959 PMID: 15919517
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Keywords: Tautomycetin, Tautomycetin supplier, Selective, PP1, inhibitors, inhibits, Calcineurin, Protein, Ser/Thr, Phosphatases, immunosuppressants, transplant, PP2, TC, Immunosuppressants, 2305, Tocris Bioscience
17 Citations for Tautomycetin
Citations are publications that use Tocris products. Selected citations for Tautomycetin include:
Georgilis et al (2018) PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell 34 85 PMID: 29990503
Wan et al (2018) M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation. Front Mol Neurosci 11 287 PMID: 30186110
Hiraga et al (2017) Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation. EMBO Rep 18 403 PMID: 28077461
Engmann et al (2015) DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nat Commun 6 10099 PMID: 26639316
Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. PLoS Genet 7 62 PMID: 25071439
Hégarat et al (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. Anticancer Res 10 e1004004 PMID: 24391510
Walsh and Young (2011) TGF-β regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1. Anticancer Res 31 3159 PMID: 21965722
Pribiag and Stellwagen (2013) TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors. Front Neurosci 33 15879 PMID: 24089494
Toledo et al (2013) A novel effect of MARCKS phosphorylation by activated PKC: the dephosphorylation of its serine 25 in chick neuroblasts. PLoS One 8 e62863 PMID: 23634231
Garzón et al (2019) Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling. Cell Rep 27 2558 PMID: 31141682
Messal et al (2019) Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. Nature 566 126 PMID: 30700911
Alver et al (2017) Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1. Cell Rep 18 2508 PMID: 28273463
Walsh and Young (2010) Interrelationship between protein phosphatase 1 and TGF-{β} in regulating motility and cytoskeletal architecture of endothelial cells. J Neurosci 30 4861 PMID: 21187463
Pyo et al (2018) ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation. Cell Rep 25 2878 PMID: 30517873
Liu (2018) In vivo brain GPCR signaling elucidated by phosphoproteomics. Science 360 eaao4927 PMID: 29930108
Huang et al (2014) PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF. Am J Physiol Cell Physiol 306 C167 PMID: 24196533
Isensee et al (2014) Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci 127 216 PMID: 24190886
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