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Submit ReviewPravastatin sodium salt
Description: HMG-CoA reductase inhibitor
Alternative Names: Eptastatin sodium
Chemical Name: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid monosodium salt
Purity: ≥98% (HPLC)
Biological Activity for Pravastatin sodium salt
Pravastatin sodium salt is a water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties.
Compound Libraries for Pravastatin sodium salt
Pravastatin sodium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Pravastatin sodium salt
| M. Wt | 446.51 |
| Formula | C23H35NaO7 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 81131-70-6 |
| PubChem ID | 16759173 |
| InChI Key | VWBQYTRBTXKKOG-IYNICTALSA-M |
| Smiles | [Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pravastatin sodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.65 | 100 | |
| DMSO | 44.65 | 100 |
Preparing Stock Solutions for Pravastatin sodium salt
The following data is based on the product molecular weight 446.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.2 mL | 22.4 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Product Datasheets for Pravastatin sodium salt
References for Pravastatin sodium salt
References are publications that support the biological activity of the product.
Hamelin and Turgeon (1998) Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. TiPS 19 26 PMID: 9509899
If you know of a relevant reference for Pravastatin sodium salt, please let us know.
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Keywords: Pravastatin sodium salt, Pravastatin sodium salt supplier, HMG-CoA, reductases, inhibitors, inhibits, statins, Eptastatin, sodium, Reductase, 2318, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Pravastatin sodium, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
3 Citations for Pravastatin sodium salt
Citations are publications that use Tocris products. Selected citations for Pravastatin sodium salt include:
Ding et al (2016) AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque Stability. Circ Res 119 718 PMID: 27439892
Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942
Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT. Proc Natl Acad Sci U S A 2 1176 PMID: 22202492
Do you know of a great paper that uses Pravastatin sodium salt from Tocris? Please let us know.
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