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Submit ReviewGBR 12935 dihydrochloride
Description: Selective dopamine uptake inhibitor
Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
Biological Activity for GBR 12935 dihydrochloride
GBR 12935 dihydrochloride is a potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).
Technical Data for GBR 12935 dihydrochloride
| M. Wt | 487.51 |
| Formula | C28H34N2O.2HCl |
| Storage | Desiccate at -20°C |
| CAS Number | 67469-81-2 |
| PubChem ID | 11957553 |
| InChI Key | NQWRSILGEXNJIT-UHFFFAOYSA-N |
| Smiles | Cl.Cl.C(CN1CCN(CCOC(C2=CC=CC=C2)C2=CC=CC=C2)CC1)CC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GBR 12935 dihydrochloride
References for GBR 12935 dihydrochloride
References are publications that support the biological activity of the product.
Andersen et al (1987) Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the DA uptake complex. J.Neurochem. 48 1887 PMID: 2952763
Reith et al (1994) GBR 12909 and 12935 block DA uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 253 175 PMID: 8013544
Reith et al (1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and DA to the DA transporter. Eur.J.Pharmacol. 227 417 PMID: 1446712
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Keywords: GBR 12935 dihydrochloride, GBR 12935 dihydrochloride supplier, Selective, dopamine, uptake, inhibitors, inhibits, DAT, Transporters, Monoamine, Neurotransmitter, GBR12935, dihydrochloride, Dopamine, 0514, Tocris Bioscience
Citations for GBR 12935 dihydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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