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Submit ReviewGBR 13069 dihydrochloride
Description: Potent dopamine uptake inhibitor
Chemical Name: (1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
Biological Activity for GBR 13069 dihydrochloride
GBR 13069 dihydrochloride is a potent inhibitor of dopamine uptake (IC50 = 40 nM). Centrally active following systemic administration in vivo.
Technical Data for GBR 13069 dihydrochloride
| M. Wt | 521.48 |
| Formula | C28H30F2N2O.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 67469-45-8 |
| PubChem ID | 24978531 |
| InChI Key | ZBSZWEYIIGLGSX-RDRKJGRWSA-N |
| Smiles | FC(C=C2)=CC=C2C(OCCN3CCN(C/C=C/C4=CC=CC=C4)CC3)C1=CC=C(F)C=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GBR 13069 dihydrochloride
References for GBR 13069 dihydrochloride
References are publications that support the biological activity of the product.
Heikkila et al (1984) Behavioural properties of GBR12909, GBR13069 and GBR13098: specific inhibitors of DA uptake. Eur.J.Pharmacol. 103 241 PMID: 6237922
Mayer et al (1986) Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport. J.Neurochem. 47 1073 PMID: 3489072
Van der Zee and Hespe (1985) Interaction between substituted 1-[2-diphenylmethoxyethyl]piperazines and DA receptors. Neuropharmacology 24 1171 PMID: 4094653
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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