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Submit ReviewL-Glutamic acid
Description: Endogenous, non-selective glutamate receptor agonist
Chemical Name: (S)-1-Aminopropane-1,3-dicarboxylic acid
Biological Activity for L-Glutamic acid
L-Glutamic acid is a the predominant excitatory transmitter in the mammalian central nervous system. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors.
MNI-caged-L-glutamate (Cat. No. 1490) also available.
Technical Data for L-Glutamic acid
| M. Wt | 147.13 |
| Formula | C5H9NO4 |
| Storage | Store at RT |
| CAS Number | 56-86-0 |
| PubChem ID | 33032 |
| InChI Key | WHUUTDBJXJRKMK-VKHMYHEASA-N |
| Smiles | [H][C@@](CCC(O)=O)(N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-Glutamic acid
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 100 |
Preparing Stock Solutions for L-Glutamic acid
The following data is based on the product molecular weight 147.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.8 mL | 33.98 mL | 67.97 mL |
| 5 mM | 1.36 mL | 6.8 mL | 13.59 mL |
| 10 mM | 0.68 mL | 3.4 mL | 6.8 mL |
| 50 mM | 0.14 mL | 0.68 mL | 1.36 mL |
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Product Datasheets for L-Glutamic acid
References for L-Glutamic acid
References are publications that support the biological activity of the product.
Monaghan et al (1989) The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system. Annu.Rev.Pharmacol.Toxicol. 29 365 PMID: 2543272
Watkins and Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965
Yang and Stockwell et al (2016) Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 26 165 PMID: 26653790
If you know of a relevant reference for L-Glutamic acid, please let us know.
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Keywords: L-Glutamic acid, L-Glutamic acid supplier, Endogenous, non-selective, agonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, mGlu, Ferroptosis, Amino, Acids, 0218, Tocris Bioscience
9 Citations for L-Glutamic acid
Citations are publications that use Tocris products. Selected citations for L-Glutamic acid include:
Kopach et al (2022) Multi-target action of beta -alanine protects cerebellar tissue from ischemic damage. Cell Death Dis 13 747 PMID: 36038575
Calò et al (2005) Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons. J Neurosci 25 2245 PMID: 15745950
Schitine et al (2015) Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input. J Neurosci 82 42 PMID: 25700791
Galici et al (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther 318 173 PMID: 16608916
Owaisat et al (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett 525 12 PMID: 22877698
Tallarida et al (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 42 2521 PMID: 21850438
Moreno et al (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287 44301 PMID: 23129762
Falcucci et al (2019) Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model. ACS Chem Neurosci 10 3437 PMID: 31257852
Moreno et al (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. J Neurosci 31 1863 PMID: 21289196
Do you know of a great paper that uses L-Glutamic acid from Tocris? Please let us know.
Reviews for L-Glutamic acid
Average Rating: 4.7 (Based on 3 Reviews.)
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Action of felbamate and beta-alanine on NMDA receptors.
By
Anonymous on 06/21/2023
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Cerebellum
Glutamic acid (10 mM) + glycine (10 mM) were used to activate NMDA receptors in outside-out membrane patch and then test action of beta-alanine and felbamate on glycine binding site. As expected, activation of NMDARs was fully legible.
Neuron glia culture.
By
Anonymous on 07/12/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Mixed neuron-glia
L-glutamate (10 or 100μM)
Incubate for 24h
works good.
By
Anonymous on 04/04/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Sprague-Dawley rats primary neuronal
10 μM L-Glutamic acid for 2 hours
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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