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H-9 dihydrochloride

Cat. No. 0396 Submit a Review Datasheet / COA / SDS

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0396 has been discontinued.

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Description: Protein kinase inhibitor
Chemical Name: N-(2-Aminoethyl)-5-isoquinolinesulfonamide dihydrochloride
Purity: ≥99% (HPLC)
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Biological Activity Technical Data Datasheets References

Biological Activity for H-9 dihydrochloride

Protein kinase inhibitor. Inhibits PKA (Ki = 1.9 μM), PKG (Ki = 0.9 μM), CaMK II (Ki = 60 μM), PKC (Ki = 18 μM), casein kinase I (Ki = 110 μ M) and casein kinase II (Ki > 300 μM).

Technical Data for H-9 dihydrochloride

M. Wt 324.22
Formula C11H13N3O2S.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 116700-36-8
PubChem ID 2735333
InChI Key HBLCYSFLYMHCBM-UHFFFAOYSA-N
Smiles Cl.Cl.NCCNS(=O)(=O)C1=CC=CC2=CN=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for H-9 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for H-9 dihydrochloride

References are publications that support the biological activity of the product.

Hidaka et al (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23 5036 PMID: 6238627

Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377 PMID: 1605572

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