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Submit Review(R)-(+)-HA-966
Description: NMDA partial agonist/antagonist; acts at glycine site
Chemical Name: (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one
Purity: ≥98% (HPLC)
Biological Activity for (R)-(+)-HA-966
(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier.
S-enantiomer also available.
Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.
Technical Data for (R)-(+)-HA-966
| M. Wt | 116.12 |
| Formula | C4H8N2O2 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 123931-04-4 |
| PubChem ID | 6603720 |
| InChI Key | HCKUBNLZMKAEIN-GSVOUGTGSA-N |
| Smiles | N[C@@H]1CCN(O)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (R)-(+)-HA-966
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.61 | 100 |
Preparing Stock Solutions for (R)-(+)-HA-966
The following data is based on the product molecular weight 116.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 8.61 mL | 43.06 mL | 86.12 mL |
| 5 mM | 1.72 mL | 8.61 mL | 17.22 mL |
| 10 mM | 0.86 mL | 4.31 mL | 8.61 mL |
| 50 mM | 0.17 mL | 0.86 mL | 1.72 mL |
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Product Datasheets for (R)-(+)-HA-966
References for (R)-(+)-HA-966
References are publications that support the biological activity of the product.
Kemp and Priestley (1991) Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-MthD.-aspartate receptor agonist responses in cat cultured cortical neurons. Mol.Pharmacol. 39 666 PMID: 1674587
Pullan et al (1990) Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-MthD.-aspartate receptor complex. J.Neurochem. 55 1346 PMID: 1975835
Pullan et al (1991) Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966). Eur.J.Pharmacol. 208 25 PMID: 1834473
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Keywords: (R)-(+)-HA-966, (R)-(+)-HA-966 supplier, Partial, NMDA, agonists, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, merck, 0281, Tocris Bioscience
1 Citation for (R)-(+)-HA-966
Citations are publications that use Tocris products. Selected citations for (R)-(+)-HA-966 include:
Paquette et al (2008) σ ligands, but not N-MthD.-aspartate antagonists, reduce levodopa-induced dyskinesias. Elife 19 111 PMID: 18281903
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